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Pathology addendum — receptor studies
Record type: addendum to the surgical pathology report of 08/26/2026, as downloaded
from the patient portal on 09/06/2026.
Stand-in for: surgical-pathology-report-SP26-XXXXX-addendum-1.pdf (invented document),
page 1 of 1.
Reporting clinician: pathologist, regional hospital pathology department.
ADDENDUM 1 · Reported: 09/02/2026 · Refers to: Specimen A, block A1
PROGNOSTIC AND PREDICTIVE MARKER STUDIES, right breast core needle biopsy, invasive carcinoma:
| Marker | Result | Detail |
|---|---|---|
| Estrogen receptor (ER) | POSITIVE | 95% of tumor cell nuclei, strong staining intensity |
| Progesterone receptor (PR) | POSITIVE | 70% of tumor cell nuclei, moderate staining intensity |
| HER2 (immunohistochemistry) | NEGATIVE | Score 1+ (faint, incomplete membrane staining in >10% of tumor cells); in situ hybridization not indicated for a 1+ result |
| Ki-67 proliferation index | 18% | Assessed in the invasive component |
COMMENT: Immunohistochemical stains were performed on formalin-fixed, paraffin-embedded tissue with appropriate controls. Scoring and reporting follow current national guidelines for breast biomarker testing. Results should be interpreted in the context of the full clinical picture by the treating clinicians.
Electronically signed by the reporting pathologist, 09/02/2026 11:08.
Family note (not part of the report): this addendum appeared in Mom’s portal on September 6, four days after it was signed. It was not in the packet we uploaded to the second-opinion office on September 5. See the transfer record.