An illustration · invented records · this source is real
Adjuvant Chemotherapy Use for Hormone Receptor-Positive, ERBB2-Negative Breast Cancer After RxPONDER Trial
Freeman JQ, Saha P, Peiffer DS, Chen N, et al. (2025). JAMA Network Open. PubMed 41632146 · DOI 10.1001/jamanetworkopen.2025.49109 · PubMed record
What kind of source: Retrospective cohort, US National Cancer Database, about half a million women. Where it sits in the summary: Still being studied. Back to the summary
What it says, in plain language
How US practice actually changed. Among postmenopausal women with low or intermediate scores, chemotherapy use kept falling through 2022. The authors also name an open question about why chemotherapy helps younger women.
Full paper in this folder: yes. Read the whole article (CC BY, reproduced in full from the publisher’s XML).
The exact words we relied on
“Among postmenopausal women with node-negative tumors, adjuvant chemotherapy use decreased from 2.6% in 2010 to 0.4% in 2022 for the low genomic risk group and decreased from 15.0% in 2010 to 1.1% in 2022 for the intermediate genomic risk group.” — PMID:41632146, Results > Patterns of Adjuvant Chemotherapy Use ¶2
“It is unclear whether some of the potential benefits of adjuvant chemotherapy in this premenopausal population are due to chemotherapy-induced menopause rather than the direct cytotoxic effect of chemotherapy.” — PMID:41632146, Discussion ¶2
“Age was used as a proxy for menopause status, and potential misclassification of menopause status is possible.” — PMID:41632146, Discussion > Strengths and Limitations ¶2
How these quotes were checked
Follow the passage links above to the included paper or public source record.
Full text, publisher XML. The publisher’s XML was retrieved and the quotes were checked against it by exact string match. The locator in brackets is the section and paragraph in that XML.
Limits of this source
Registry data: it shows what was prescribed, not what worked. Menopausal status was inferred from age. Open access (CC BY); full text in this folder.
Review
Reviewed by Sarah Kiselycznyk · September 10, 2026. Review scope and verification method: How we researched this.